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Regulatory T Cells (Tregs) as a Possible Prognostic Marker in Radiation Skin Injury

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Etiquetas

  • pacientes
  • proteccion contra las radiaciones
  • piel
  • guias
  • lesiones
  • eritema

Datos

Origen

Argentina

Idioma

Español

Organización

ARN (Argentina)

Autor

Molinari, A.J.; Portas, M.; Rossini, A.; Michelin, S.; Dubner, D

Previsualización

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Descripción

Radiation skin injury (RSI) has been reported in patients that underwent fluoroscopically guided procedures. RSI ranges in severity from mild erythema to moist desquamation and ulceration. Radiation induced skin injury can be divided into acute and chronic. Acute injury occurs in hours to weeks after irradiation exposure, whereas chronic includes ulcers and fibrosis that persist weeks to years after radiation exposure. Chronic inflammation has been associated to RSI. Human survival from injury and wound healing require an

appropriate inflammatory and immune response. Regulatory T cells (Tregs) belong to a unique subpopulation of CD4+ lymphocytes. It has been demonstrated that CD127 expression is an excellent biomarker of human Tregs, especially when combined with CD25, in this CD4+ lymphocytes. Tregs represent 5-10% of peripheral CD4+ cells in normal condition in humans and have an important role in mediating immune homeostasis, as well as maintaining self-tolerance. Several studies about Treg cell radiosensitivity indicated that Tregs were more radioresistant than other T or B lymphocyte subpopulation. Repeated low dose irradiation has been shown to suppress inflammation in different autoimmune and allergic conditions in part to upregulation of Tregs. Tregs

could accumulate at inflammatory sites induced by ionizing radiation and could influence the level of DNA damage and repair through TGFβ production in responder cells. Within this context, the aim of the present study was to evaluate the percentage of Tregs by flow cytometry in patients exposed to fluoroscopy. We particularly analyzed the frequency of CD4+ CD25+ CD127-. Changes in the level of circulating Tregs in the peripheral blood, in combination with other inflammatory parameters, might be very important for RSI prognosis. Additionally, Tregs could be used as a potential follow up biomarker of the radio induced inflammation process in a radiological accidental scenario and could contribute to efficiently guide a personalized therapeutic treatment. 14th International Congress on the International Radiation Protection Association. Cape Town, Sudáfrica, 9 al 13 de mayo de 2016